Grant to PU Faculty
National Tel24 News
Vinay
Kumar
Chandigarh
A project
entitled " Structure-Activity relationship studies of a novel
Two-component lantibiotic Roseocin " has been approved for
funding by DST-SERB, New Delhi, Govt. of India to Dr. Dipti Sareen,
Department of Biochemistry, Panjab University, Chandigarh wherein
the project carries the Equipment grant worth Rs.19,75,000/- and consumables worth
Rs.12,00,000/- alongwith the grant for Manpower (JRF), Travel, Contingency and Overhead,
as per norms, for a period of 3 years. Prof. Raj Kumar PU VC, assured of
all the support required to successfully carry out the approved
project. The project aims to address the global challenge of antimicrobial
resistance (AMR) by ribosomally synthesized and
post-translationally modified anti-microbial eptides, also known as
‘lantibiotics’. These are emerging as more promising drugs against
antibiotic resistant bacteria since a significant resistance development against
lantibiotics takes a long time as compared to antibiotics. Earlier
studies in this lab, have already established the biosynthesis of a novel lantibiotic,
Roseocin from an actinomycete, whereby a genetically engineered expression
system enabling the independent production of fully modified and matured components
of a lantibiotic in E. coli host strain was achieved. The expression system developed
in this study constitutes an important cornerstone for the proposed in vivo peptide
engineering studies and is of significance for potential applications aiming at
higher production titres of ribosomally synthesised, post translationally
modified peptides. In order to fully realize the potential
of newly discovered peptide lantibiotic, Roseocin, it is necessary
to understand the biology and, in particular, to elucidate their
structure -function relationships and mode of action.
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